PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC
نویسندگان
چکیده
منابع مشابه
Altered glutamine metabolism in platinum resistant ovarian cancer
Ovarian cancer is characterized by an increase in cellular energy metabolism, which is predominantly satisfied by glucose and glutamine. Targeting metabolic pathways is an attractive approach to enhance the therapeutic effectiveness and to potentially overcome drug resistance in ovarian cancer. In platinum-sensitive ovarian cancer cell lines the metabolism of both, glucose and glutamine was ini...
متن کاملRB in glutamine metabolism
In a majority of cancer cells, inactivation of the retinoblastoma protein (pRB) through hyperphosphorylation, deletion, or mutation leads to dissociation from E2F effector proteins and aberrant activation of downstream target genes. Suppression of pRB function ultimately results in the loss of regulatory control over multiple biochemical pathways required for tumorigenesis, including cell cycle...
متن کاملAvian mitochondrial glutamine metabolism.
Intact avian liver mitochondria were shown to synthesize glutamine from glutamate in the absence of exogenous ATP and ammonia. With L-[U-14C]glutamate as the substrate, there was an approximate 1:1 stoichiometry between glutamate deaminated (as measured by the release of 14CO2 due to alpha-keto-[14C]glutarate oxidation) and glutamate amidated. With L-[15N]glutamate as the substrate, the isolate...
متن کاملAbout sorafenib in castration-resistant prostate cancer.
In the study design of Chi et al. [1] is declared that sorafenib would be considered of interest if three or more prostatespecific antigen (PSA) responses were observed in the 25 patients accrued. In their trial, a PSA response occurred in one patient among 28 patients treated with sorafenib; therefore, sorafenib should be considered ineffective in chemonaive castration-resistant prostate cance...
متن کاملSalmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress
The adaptations that protect pathogenic microorganisms against the cytotoxicity of nitric oxide (NO) engendered in the immune response are incompletely understood. We show here that salmonellae experiencing nitrosative stress suffer dramatic losses of the nucleoside triphosphates ATP, GTP, CTP, and UTP while simultaneously generating a massive burst of the alarmone nucleotide guanosine tetrapho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2017
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-17-0061